Evidence quality

Confounding

When another factor partly or fully explains an apparent association.

What it means

Definition

Confounding: Confounding occurs when groups differ in ways that affect the outcome. It is a major limitation of observational evidence.

What it can tell you

It can help separate an observed association from a tested causal claim.

What it cannot tell you

It cannot remove confounding or prove causation without stronger study design and analysis.

Headline trap

Why this matters in headlines

People who take supplements may also exercise more, eat differently, or be wealthier, which can confound associations.